Thursday, May 23, 2013

The Irish loophole behind Apple's low tax bill

By Tom Bergin

LONDON (Reuters) - Apple's ability to shelter billions of dollars of income from tax has depended on an unusual loophole in the Irish tax code that helps the country compete with other countries for investment and jobs.

A U.S. Senate investigation revealed Tuesday that Apple, maker of iPhones, iPads and Mac computers, channeled profits into Irish-incorporated subsidiaries that had "no declared tax residency anywhere in the world.

Apple said on Tuesday that the arrangements dated back over 30 years and had been negotiated with Ireland's government, which has long angered European economic peers such as France and Germany by helping multinationals to avoid paying tax on sales it makes to their citizens in their domestic markets.

Apple's annual reports show that over the past three years, Apple paid taxes worth 2 percent of its $74 billion in overseas income.

Apple now channels most of its overseas sales through three companies that are incorporated in Ireland but for tax purposes are resident in no jurisdiction. U.S. rules that allow companies incorporated abroad not to pay U.S. taxes complement that arrangement.

Apple tax head Phillip Bullock told the U.S. Senate Permanent Subcommittee on Investigations on Tuesday that one of these three subsidiaries, Apple Operations International (AOI), had not submitted a tax return anywhere for five years.

All three were registered in Ireland in 1980 and reregistered as unlimited companies in 2006, which means under Irish law that they do not have to publish annual accounts, so the subcommittee's report was the first time the current structure had been publicly revealed.

Peter Vale, tax partner at accountants Grant Thornton in Dublin, said it was unusual for companies incorporated in Ireland not to be tax resident there, but it is legal.

Apple relies for tax benefits on contrasting approaches to determining tax residence in Ireland and the United States.

Vale said that if a group has at least one trading Irish subsidiary - as Apple does, in the form of units that employ 4,000 staff - it can establish a corporation that will not be deemed tax resident in Ireland providing this unit's "central management control" is outside the country.

The subcommittee said AOI and Apple Sales International (ASI) held board meetings in the United States and most board members were based there. That means the units would not be deemed to have Irish management control, accountants said.

Apple documents released by the subcommittee showed that current Chief Executive Tim Cook and current Chief Financial Officer Peter Oppenheimer were board members of all three Irish units during the late 2000s, typically holding their meetings at Apple headquarters in Cupertino, California.

Apple told the subcommittee that AOI has no employees and no physical address. Its assets are managed by employees at a subsidiary, Braeburn Capital, located in Nevada, while the assets are held in bank accounts in New York. Primary accounting records are maintained at Apple's U.S. shared service center in Austin, Texas.

Despite this, AOI did not have tax residency in the United States, because, said Lyn Oates, professor of tax and accounting at the University of Exeter Business School in the UK, the United States determines tax residence on the place of incorporation only.

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Britain also used to allow companies to be incorporated there without being tax resident, but changed its system over 20 years ago to stop tax avoidance, said Penelope Tuck, associate professor of public finance and policy at the University of Warwick.

Ireland did not change its rules, probably because there was not the same concern about the loss of tax revenues, said Professor Eamonn Walsh, professor of accounting at University College Dublin's Graduate School of Business.

Ireland's small population of 4.6 million means multinationals generate relatively little by way of sales or profits there.

"From a policy point of view, people are more concerned with the idea that high-paid jobs are being delivered to the local economy," Walsh said.

Apple originally expanded to business-friendly Ireland as a gateway to Europe, opening a factory there, former CEO John Sculley and other former executives told Reuters.

Cook told the subcommittee that Apple was attracted to Ireland in 1980, when the country was offering incentives to technology companies as it tried to build an industrial base.

Over the years, the structures Apple uses have evolved, and the support of the Irish government has continued.

"Since the early 1990s, the government of Ireland has calculated Apple's taxable income in such a way as to produce an effective rate in the low single digits," Apple tax chief Bullock testified.

A Reuters analysis of Apple's annual reports shows that Apple's overseas tax rate really began to hit rock bottom in the late 1990s, after the United States began to let companies avoid tax on overseas earnings in what became known as the "check-the-box" (CTB) loophole.

From 1993 to 1995, three years before CTB emerged, Apple had an effective overseas tax rate of 16 percent. The rates later plummeted and have averaged 2 percent in the past three years.

One former official with the Irish Development Authority, which had the task of enticing foreign companies to invest in Ireland, said that after the introduction of CTB in the United States, companies began to demand better tax deals in Ireland.

While the Senate subcommittee referred to Apple's negotiating tax rates of below 2 percent, Ireland usually facilitates low tax payments not by undercutting its highest corporate tax rate of 12.5 percent but by allowing companies to declare low taxable profits - often by making deductions for payments to tax-exempt affiliates, usually offshore.

Ireland said the low tax payment was not its fault and blamed other countries' tax legislation.

Apple's exact arrangements in Ireland have changed over the years.

Up until 2004 or later, the three Apple companies were assessed for taxation in Ireland, although the declared profits were much lower then.

In 2004, ASI declared a profit of $325 million and paid Irish tax of $21 million, its accounts from the time show.

In 2011, according to the subcommittee's report, ASI earned $22 billion and paid just $10 million in "global taxes."

Apple's retail units in France, Germany and Britain purchase goods from the Irish units. The prices are set at levels that ensure these units in bigger states do not report much profit.

This means the company avoids tax on sales in its bigger markets.

In 2011, the last year for which accounts are available, Apple Retail UK Ltd reported profits of 31 million pounds on sales of 860 million pounds and paid tax of 9 million pounds.

In the same year, Apple Retail France reported a loss of 21 million euros on sales of 346 million euros and paid income tax of 7 million euros.

Apple Retail Germany reported a 4 million euro loss on sales of 174 million euros and paid no income tax.

Other jurisdictions also offer tax advantages like Ireland.

Online retailer Amazon.com Inc pays low taxes on overseas income by channeling European sales through a Luxembourg-based company that makes untaxed payments worth hundreds of millions of euros each year to a tax-exempt partnership, also resident in Luxembourg.

Google pays low taxes by directing overseas sales through an Irish unit that pays most of its income to an affiliate in Bermuda.

The schemes used by all three companies work by arranging for the units that make sales to customers in Europe and elsewhere to make tax-deductible payments to untaxed, or little taxed, affiliates for the use of intellectual property such as brands and business processes.

The Group of 20 leading nations has asked the Organisation for Economic Co-operation and Development to look at such corporate profit-shifting. One area it is examining closely is such payments for intangible assets.

The companies say they follow the tax rules in all the countries where they operate.

(Additional reporting by Jonathan Weber, Poornima Gupta, Edwin Chan and Peter Henderson in San Francisco; Editing by Will Waterman, Alastair Macdonald and Prudence Crowther)

Source: http://news.yahoo.com/irish-loophole-behind-apples-low-tax-bill-003322241.html

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Drew Barrymore Selling Off Wedding House in Montecito - Curbed LA

Tuesday, May 21, 2013, by Adrian Glick Kudler






Peak Fitness and Nutrition: Today's Natural Cure: A Healthy Gut

This article is from? greenmedinfo.com

At her Cambridge Nutrition Clinic established in England in 1998, Dr. Campbell-McBride traces the connection between neurology and nutrition as well as digestion and the functioning of the rest of the body. "The digestive system holds the root of our health," she says pointing out the extensive role that gut flora plays in disease prevention, including protecting us from invading pathogens, detoxification, facilitating the digestion of food as well as the absorption of vitamins and minerals like calcium and zinc, and actually producing B vitamins. In addition, between 84-88% of the immune system is housed in the gut lining, she says, which would equal the size of a tennis court if opened up and laid flat .

"There cannot be cancer in the digestive tract if the gut flora is healthy," asserts Dr. Campbell-McBride, a medical doctor with postgraduate degrees in both neurology and human nutrition. But in today's society, many people are walking around with impaired gut flora due to steroids, prescription medications, alcohol, stress, a poor diet of processed foods and sugar (which actually feed abnormal gut flora), disease, age, bottle feeding of infants, toxic chemicals, pollution and radiation.

A major cause of impaired gut flora are antibiotics and she worries about teenagers being treated for up to two years with?acne drugs, leaving them with serious damage. Dr. Campbell-McBride points to a study showing that rats treated with antibiotics succumb tomercury poisoning?while those with untreated gut flora do not. She believes the same is true of humans and that, while the government warns against eating fish because of mercury and PCB contamination, a healthy gut should be able to tolerate the exposure and get the health benefits of eating fish. According to Dr. Campbell-McBride, as a population we are degrading healthy gut flora more and more every generation. Mothers who have been on the Pill or antibiotics or a poor diet for long periods develop abnormal gut flora and pass it on to their children. This, she believes, has led to an epidemic of eczema and?autism, noting that 20 years ago the autism rate was 1 in 10,000 children and today is 1 in 88. When children are born with their mothers' unhealthy gut, they have immune compromised systems, develop ear and chest infections and are treated with antibiotics.? All this creates more damage to their systems.?As the gut wall suffers more damage, it becomes "leaky"?and allows undigested food to enter the blood stream resulting in more prevalent food allergies, such as to peanuts. As their systems become more and more damaged, these immune compromised children are subjected to?multiple vaccines?designed for children with healthy immunity. But with impaired immune systems, she contends, these children suffer mental and?developmental disabilities.

A poorly functioning gut can give rise to a wide range of seemingly unrelated problems, some of them very surprising. According to Dr. Campbell-McBride,?a bad gut can manifest as asthma, allergies, eczema, chronic cystitis, bed wetting, sinusitis, post-nasal drip, rhinitis, gingivitis or vaginitis.

It can also lead to a variety of auto-immune conditions in which the immune system produces antibodies to attack its own tissues. In Type 1 diabetes, she says, the pancreas is attacked, in?celiac disease?the small intestine is attacked and in multiple sclerosis and schizophrenia, it is the nervous system. Other conditions that can arise are arthritis, fibromyalgia and chronic fatigue.

In childhood, a compromised gut can lead to autism; ADHD/ADD; dyslexia;?dyspraxia?(a developmental co-ordination disorder); learning, behavior and social problems; and epilepsy. As these children enter their adult years, it can lead to substance abuse, depression, obsessive compulsive disorder, manic depression and schizophrenia.

Even?eating disorders, which are typically treated as psychiatric or psychological conditions, says Dr. Campbell-McBride, can start with nutritional deficiencies very often arising from vegetarianism in young girls. She believes that as girls progress from vegetarianism to veganism, they cut more and more healthy fats out of their diets, especially vitamins A and D, and are left with a compromised immune system. They then develop mononucleosis or scarlet fever, and are treated with antibiotics, further damaging their gut. Eventually, she says, this leads to an altered sense of self-perception and?anorexia. Dr. Campbell-McBride's treatment is to provide low calorie beef broth and vegetable soup with a regimen of supplements, including high doses of amino acids, B vitamins, vitamins A and D,?zinc?and essential fatty acids. In her experience, it takes about two to four weeks for the patient's neurotransmitters to restore self-perception. Dr. Campbell-McBride calls this "Bingo Day," when a patient can finally see herself as emaciated instead of fat.

Source: http://peakfitnessandnutrition.blogspot.com/2013/05/todays-natural-cure-healthy-gut.html

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Wednesday, May 22, 2013

3M, Nanosys ready to bring quantum dot film to LCD makers

3M's upcoming quantum dot film brings 50 percent more color to LCDs

3M and Nanosys have just announced that they'll start shipping qualification samples of their Quantum Dot Enhancement Film (QDEF) to manufacturers to bring a 50 percent wider color gamut and lower power consumption to LCD displays. Consisting of trillions of quantum dots tuned to create precise color hues, such films can be swapped in to replace existing backlighting tech, meaning manufacturers will need no special equipment to adopt it. The companies say they'll have samples for manufacturer design cycles starting "late second quarter this year" -- but if you can't wait that long, you'll be able to actually buy similar tech from Sony, likely very soon.

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Source: http://www.engadget.com/2013/05/22/3m-nanosys-ready-to-bring-quantum-dot-film-to-lcd-makers/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Tuesday, May 21, 2013

Gringos In The Slums: Expats Move In As Rio Favelas Improve ...

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    Gringos In The Slums: Expats Move In As Rio Favelas Improve Gentrification Rate Topic: -----

    #1 User is offline ? Eddie_George?

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    Posted Yesterday, 12:22 PM

    Quote

    Now that the notorious drug gangs of Rio de Janiero's shanty towns have been driven out, the neighborhoods are attracting new residents from Southern Europe. Fleeing the euro crisis back home, the expats are contributing to a real estate boom in the favelas.

    A gentle wind blows across Ipanema, and the air is soft and velvety. Diego Baronio hails from Brescia near Milan, yet here he is, high above the beach at Rio de Janeiro. He has just placed a fruit basket with papaya on the table, the espresso machine is hissing, and his Brazilian companion is serving freshly squeezed pineapple juice. A tourist from Berlin is stretching on a lounger. Baronio has rented his guest room to him. The Italian charges 500 reais (?191/$246) per month for the room, a price that includes breakfast and a spectacular view. At the hotels in Ipanema, that amount of money is only enough for one night's accommodation with a courtyard view at most. But the hotels aren't located in a favela, or shanty town, like the apartment that Baronio has purchased. He lives in the impoverished district of Cantagalo, a rust-red labyrinth of interlaced brick buildings. The homes in these poor neighborhoods cling to the hillsides like honeycomb, far above the gated communities of Ipanema. "The people up here are poorer than those who live farther down below -- the buildings are crammed on top of each other, and trash litters the narrow streets," admits Baronio. But he says that it's not much different in many Italian cities: "I thought the favelas would be much worse." In fact, they were. Three and a half years ago, Cantagalo was controlled by gangsters. There were frequent gunfights and tourists occasionally got caught in the line of fire. Then Brazil was awarded the right to host the 2014 World Cup, which will be followed two years later by the 2016 Summer Olympics in Rio. FIFA, the international governing body of football, along with the International Olympic Committee, have been pressuring the government to crack down on crime.

    The governor of the state of Rio de Janeiro has sent in the police to occupy 30 favelas and, by the time the World Cup kicks off, a total of 40 city slums will be patrolled by Police Pacification Units, known as UPPs. The officers are assigned to well-fortified police stations and are at the core of a new security policy. Cantagalo was "pacified" in this manner. The gangsters fled and the city administration built sewage pipes, sent in garbage collectors and promised to legalize the illegally built homes of local residents.

    Growing Expat Community Now, the real estate market is booming in these favelas. Middle-class Brazilians have discovered the slums as a cheap housing alternative. They are also accompanied by an influx of foreigners, most of whom come from the crisis-ridden countries of Southern Europe. Many of the newcomers head to Rio to build an entirely new life for themselves. Cantagalo is now home to Spaniards, Italians, Argentineans and an Australian. In the neighboring favela of Pav?o-Pav?ozinho, a prominent immigrant from Germany has also found a place to live: the former senator of the interior in the city-state of Hamburg, Ronald Schill, who was once called "Judge Merciless" for his harsh rulings. Until recently, he was living in an apartment on the Copacabana. Now, he has purchased a small house in the favela. "Rents and purchasing prices are lower here than down below," says as he points to the asphalt jungle at his feet. It's primarily the favelas in the southern zone of the city that attract the gringos. These areas are usually only minutes from the beach and offer some of the best views of Rio's stunning urban landscape.

    Standing on his terrace, Baronio gazes at the Atlantic. It takes him only 15 minutes to get to the beach. "In Europe the rich would live here," he says in amazement. In 2010, he paid 60,000 reais, or approx. ?23,000/$29,500, for his apartment, which is located in a three-story building directly adjacent to the police station. Baronio made his first trip to Rio four years ago. At the time, he only wanted to spend his vacation here. Then he met his current boyfriend, Alex, fell in love and settled in Brazil. In Italy he was as a social worker -- in Rio he works for an aid organization. "The mood is miserable in Italy," he says, adding that "here at least people are cheerful." The Rio municipal government is promoting this immigration. Politicians hope that the new residents will help prevent a return of the drug barons. Many immigrants transform their buildings into bed-and-breakfasts, in some cases tripling or quadrupling their value. Anyone who has a roof-top terrace with a view rents it out for parties, concerts and photo shootings.

    But there is also a downside to the real estate boom in the slums. Some owners add extra stories to their buildings, although this is prohibited. The favelas are thus growing upwards instead of expanding in surface area. Baronio is also a victim of the construction fever. The owners of both levels above him have transformed the building into a bed-and-breakfast, but apparently the work wasn't up to professional standards. Now, it leaks through the ceiling in Baronio's apartment every time someone turns on a faucet. He has complained to the neighborhood association, which is responsible for all real estate in the favela, but he was rebuffed. It turns out that the president of the organization owns a stake in the upstairs bed-and-breakfast.



    #2 User is offline ? Frizzers?

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    Posted Yesterday, 05:32 PM


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    1. Jonester76

    Source: http://www.housepricecrash.co.uk/forum/index.php?showtopic=190508

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    enviroline / low-carbon energy strategy for north america ...

    Photo of Nobel Prize Winning Scientist, Mario Molina

    ?

    By Elona Malterre

    ?

    ?????????? Creating a North American energy strategy makes ?a lot of sense? says a Nobel Prize winner and U.S. presidential advisor who also warns that not addressing climate change is like ?playing Russian roulette.?
    ?????????? While Canada?s political leaders continue to disagree over the merits of establishing a national energy strategy, the United States and Mexico are keenly interested in creating a North American energy strategy, says Mexican-born Nobel laureate Mario Molina, professor of chemistry and biochemistry at the University of California, San Diego.
    ?????????? ?It would make a lot of sense,? said Molina, who has served President Barack Obama and former president Bill Clinton on the President?s Council of Advisors on Science and Technology and also worked extensively with Mexico?s energy and environment ministries.
    ?????????? Molina is also director of the Mario Molina Center for Energy and Environment in Mexico City.
    ?????????? ?We have the support (for a North American energy strategy), and ? I have not yet communicated to our Canadian colleagues ? but certainly at very high levels in Mexico and the United States,? Molina told a meeting in Calgary of the Commission for Environmental Cooperation?s Joint Public Advisory Committee (JPAC) established under the North American Free Trade Agreement (NAFTA).
    ?????????? JPAC is a 15-member, independent volunteer body that provides advice and public input to the NAFTA environmental commission?s council (www.cec.org/council), which comprises the environment ministers from the three NAFTA countries.
    ?????????? Molina, who shared the Nobel Prize for Chemistry in 1995 for his work on compounds such as chlorofluorocarbons adversely affecting the ozone layer, was a keynote speaker at JPAC?s ?Greening North America?s Energy Economy? two-day public consultation meeting in Calgary in late April.
    ?????????? Molina said that creating a North American energy strategy was one of four recommendations that members of the President?s Council of Advisors on Science and Technology made in two recent meetings with Obama. The other recommendations included:
    ????????? ???? putting a price on carbon emissions so the marketplace can work to find the cheapest emissions reductions through a new international agreement in the post-Kyoto period;
    ????????? ???? increasing investments in energy-technology research, development and demonstration; and
    ????????? ???? expanding international cooperation on deploying advanced energy technologies.?
    ????????? Molina also told his Calgary audience that ?the world is playing Russian roulette by not addressing climate change.??
    ????????? Referring to data from the Massachusetts Institute of Technology, he noted that in the absence of an international policy to stabilize carbon dioxide levels in the atmosphere, global mean surface temperatures could rise from a minimum 3 to 4 ?C up to 7?C. (See http://www.cec.org/2013JPAC/Mario_Molina.pptx).
    ?????????? Molina, quoting an opinion piece written by climate scientists Robert Corell, Jeff Masters and Kevin Trenberth that was published in Politico in November 2012, said that ?a warming climate puts more energy into storms, including hurricanes, loading them with more rainfall and the stronger winds pushing more of a storm surge.? (See http://www.politico.com/news/stories/1112/83335.html).
    ?????????? The three climate scientists ? each at different organizations ? concluded that climate change is worsening some recent extreme weather events such as super storm Sandy. ???
    ????????? ?If experts and scientists are right about climate change, it is just a matter of time before society will naturally agree to put a price on carbon internationally,? Molina said. ?As this has a high probability of happening, why not get started right away and get ahead of the curve??
    ????????? Molina also told his Calgary audience that recent data from the Organization for Economic Co-operation and Development (OECD) revealed a global system of fossil fuel subsidies and taxes that is ?horribly overcomplicated and illogical.?
    ????????? The total value of fossil fuel subsidies in 2011 for OECD countries amounted to more than US$80 billion, with three-quarters of it going to the petroleum industry, he said.
    ????????? The OECD?s principal conclusion was that government support for oil, coal and natural gas development is still increasing across the developed world, Molina said.
    ????????? Attendees at the JPAC meeting also heard from Kent Klitgaard, co-author with Charles A.S. Hall of the new book Energy and the Wealth of Nations, which presents an economic theory for the ?second half of the age of oil.?? (Klitgaard show below)


    Kent Klitgaard????????? ?I think the world, especially North America, has got a problem . . . what I call the dilemma of economic growth,? said Klitgaard, professor of economics at Wells College in Aurora, New York. ?We grow too rapidly in the sense of using resources and putting carbon into the air.?
    ?????????? Almost all our current economic theory about energy has been developed ?on the economic upswing? based on U.S. geologist M. King Hubbert?s peak oil curve, Klitgaard said, adding that he is interested in developing ?an economic theory for the second half of the age of oil.?
    ?????????? (For a primer on Hubbert?s peak oil theory, see http://www.resilience.org/primer).
    ?????????? In Hubbert?s theory, ?what rules the (economic) down sweep is not only peak oil, although conventional oil has probably peaked . . .,? he said. ?But one must also consider the cost (of energy development) not just in dollars or pesos, but also in terms of energy invested in that (development).?
    ?????????? In their book Energy and the Wealth of Nations, Klitgaard said that co-author Hall developed ?the idea of energy return on investment, which is basically energy delivered to society divided by the energy invested in that (energy development).?
    ????????? Unfortunately, Klitgaard added, ?the energy return on investment tends to be declining.?
    ????????? The average energy return on investment from the time of the first big oil find at the turn of the 20th century to the 1930s was about 100:1, he said.
    ?????????? By 1979 and the year of North America?s second ?oil shock,? that return on investment had declined to 40:1, Klitgaard said. ?It?s now fallen down to about 20:1.?
    ?????????? The relationship between the Sun?s energy striking the Earth, the conversion to biomass, the exploitation of biomass by human activity, the carbon sinks, and the infrared ?bounce? back of energy into space inevitably leads to the question of ?How big can the economy be relative to the ecosystem?? he said.??
    ????????? ??Anyone who believes that an economy can grow exponentially in a finite ecosystem is either a madman or an economist,?? Klitgaard said, quoting Kenneth Boulding, a founder of the International Society of Ecological Economics.
    ????????? ?Exponential growth in the economy results in exponential growth in carbon dioxide emissions when looked at absolutely,? Klitgaard said. (See http://www.cec.org/2013JPAC/Kent_Klitgaard.pptx).
    ??????????? Recently, he said, there has been a relative decoupling in the economy, and the connection between energy consumption and real GDP has been declining.
    ?????????? According to climate activists, he added, when it comes to reducing greenhouse gas emissions, ?We?ve been going the right way too slow,? due to relying on increased energy efficiencies and other ways of ?picking the low-hanging fruit.?
    ?????????? Klitgaard also pointed to another indicator of reduced global economic growth.
    ????????? ?If you look at the growth rate per decade . . . the growth rates in the ?70s were lower than they were in the ?60s, and they were lower in the ?80s than they were in the ?70s and they were about the same in the ?90s, and then even lower in the 2000?s and are hovering very low now.
    ????????? ?And if you look, Europe is stagnant. China?s growth rates are falling (which) seem to lend some credibility to stagnationist?s theory.?
    ?????????? Economic growth is powered by our ability to provide energy, so if you couple the global debt loads with increased oil prices, the question is whether the world has ?a new normal of lower economic growth,? Klitgaard said.
    ????????? ?We need far more analysis into what the feedback mechanisms between energy availability, the economy and the carbon balance of what society will be,? he added.
    ?????????? Referring to the paper, ?Beyond ?dangerous? climate change: emission scenarios for a new world,? by UK climate change scientists Kevin Anderson and Alice Bows and published in Philosophical Transactions of the Royal Society, Klitgaard said: ??It?s not possible to ensure with high likelihood that a temperature rise of more than 2 degrees Celsius can be avoided given the view that reduction in emissions of three to four per cent per year are not compatible with economic growth.?? (See http://rsta.royalsocietypublishing.org/content/369/1934/20.full).?
    ????????? ?As long as economic growth becomes the priority and anything else has to fit within that, the ability to come up with those (emissions-reduction) innovations will be highly unlikely,? Klitgaard said.
    ?????????? For North America to realign its economies to more sustainable models, he said that society must consider:
    ?????????? ???? smaller scale development;
    ?????????? ???? more local production;
    ?????????? ???? limits on speculative financing;
    ?????????? ???? work sharing;
    ?????????? ???? more equality (internationally and intra-nationally);
    ?????????? ???? getting by on less energy.
    ??????????? A sustainable North American economy can be neither Soviet-style heavy industry nor globalized monopoly finance capitalism, Klitgaard said.
    ????????? David Angus, chair of JPAC for 2013, told the Calgary audience that he was amazed at the level of research and cooperation achieved at NAFTA?s Commission for Environmental Cooperation.
    ????????? JPAC is ?empowered to provide advice (to the commission?s environment council) to the highest levels of this kind of work,? Angus said.
    ?????????? Following the public consultation meeting in Calgary, JPAC in May issued a series of practical recommendations to the top environment officials of Canada, Mexico and the United States to do more to move North America toward a truly sustainable energy economy.
    ????????? Key among the recommendations are that the three countries ?should develop a comprehensive North American low-carbon energy strategy,? and eliminate government subsidies to the fossil fuel industry in North America and support ?investments and market-based mechanisms that promote energy efficiency and renewable energy technologies.? (See http://www.cec.org/Storage/148/17443_JPAC_Advice_to_Council_13-02_en.pdf).
    ????????? Experts from industry, civil society and academia who participated in ?Greening North America?s Energy Economy? recognized that North America is rich in fossil fuel resources, but they also acknowledged the long-term danger of continuing current patterns of energy development and consumption in the region, JPAC said.
    ????????? Three clear themes emerged from the discussion:
    ?????????? ???? The need to ensure long-term availability and security of energy throughout North America with an emphasis on energy self-sufficiency within the region;
    ?????????? ???? The need to address concerns regarding climate change and the increasing amount of energy invested per unit of energy returned that is required to obtain fossil fuel energy resources; and
    ?????????? ???? The need to leverage the development of North America?s wealth of hydrocarbon energy resources to help move to a prosperous, low-carbon economy.?
    ?????????? ?We went to Calgary to listen, consult and promote conversations,? Angus said after the meeting.
    ?????????? ?What we heard is that to address risks of climate change, the region must find ways to twin the development of those resources with a rapid transition to low-carbon ways to meet North America?s long-term energy needs.?
    ????????? JPAC called on the Commission for Environmental Cooperation?s (CEC) Council (Canada?s environment minister, the U.S. Environmental Protection Agency?s administrator and Mexico?s secretary of environment and natural resources) to adopt JPAC?s key proposals as the council implements the CEC?s 2013-2014 operational plan and looks toward future priorities under the CEC?s 2015-2020 strategic plan.
    ????????? JPAC plans to host its next public meeting on transportation and the environment in Mexico on July 10-11, 2013. That meeting will be held jointly with the annual meeting of the CEC Council. EnviroLine

    Source: http://envirolinenews.ca/20130521/low-carbon-energy-strategy-for

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    Parasitic wasps use calcium pump to block fruit fly immunity

    Tuesday, May 21, 2013

    Parasitic wasps switch off the immune systems of fruit flies by draining calcium from the flies' blood cells, a finding that offers new insight into how pathogens break through a host's defenses.

    "We believe that we have discovered an important component of cellular immunity, one that parasites have learned to take advantage of," says Emory University biologist Todd Schlenke, whose lab led the research.

    The Proceedings of the National Academy of Sciences (PNAS) published the results, showing how a wasp version of a conserved protein called SERCA, which normally functions to pump calcium from the cell cytoplasm to the endoplasmic reticulum, can block a host's cellular immune response.

    "Before our study, there were hints that calcium signaling was important for blood cell activation following infection, but the fact that a parasite actively suppresses this signaling shows how important it is, Schlenke says. He adds that the insects can serve as a model for more complex human immune systems.

    "It's incredible the way the wasps use a protein in their venom to control the flies at a molecular level," says Nathan Mortimer, a post-doctoral fellow in the Schlenke lab who conducted the experiments. "Instead of killing the fly immune cells, the wasps actually take over blood-cell signaling, manipulating the host's behavior from the bottom up."

    The research team also included Emory biologist Balint Kacsoh; Jeremy Goecks and James Taylor, from Emory's departments of biology and mathematics and computer science; and James Mobley and Gregory Bowersock of the University of Alabama, Birmingham.

    Fruit flies and the tiny wasps that parasitize them have co-evolved complex strategies of attack and defense. The wasps inject their eggs into the body cavities of fruit fly larvae, along with venom that aims to suppress the flies' cellular immunity. If the flies fail to kill the wasp egg, a wasp larva hatches inside the fruit fly larva and begins to eat its host from the inside out.

    "The wasp larvae have these sharp appendages, like the fingers of Edward Scissorhands, that they use to stick into the fly tissue and start eating," Mortimer says. "It's a brutal process."

    In previous research, the Schlenke lab has shown how fruit flies sometimes use alcohol in rotting fruit as a drug to kill the wasps.

    In the current study, the researchers focused on the molecular attack strategies of the wasps. After sequencing the transcriptome of the newly described wasp species Ganaspis sp.1, they took a proteomic approach to identify peptide sequences out of the wasp's venom gland, which they could then link back to full-length transcript sequences.

    "We found that the venom of Ganaspis sp.1 is a toxic cocktail of 170 different proteins," Schlenke says, "but the most prominent component was the SERCA calcium pump protein. That really surprised us."

    Calcium pumps are found in the membranes of every living cell of every animal, and are needed to maintain ionic homeostasis and cellular stability. One type of pump moves calcium ions out of the endoplasmic reticulum and into the cytoplasm where they transmit signals that activate other proteins. The SERCA calcium pump operates in the opposite direction, sucking calcium ions out of the cytoplasm and back into storage.

    "We wondered why the wasps would inject the flies with a protein that the flies already have, and that every cell needs to function," Schlenke says. "How could that be an infection strategy?"

    The researchers knew of studies suggesting that a calcium burst in cytoplasm is associated with the activation of human blood cells. They wondered if something similar was happening with the flies.

    Mortimer conducted experiments on a transgenic fly strain with cells that fluoresce in the presence of calcium. He found that the fly blood cells release a burst of calcium into their cytoplasm, and that this activates the blood cells to start homing in on the wasp eggs. Genetically increasing or decreasing blood-cell calcium levels makes the flies more or less resistant to the parasite infection.

    "The wasp venom prevents this calcium burst, and it's like the fly blood cells don't realize they're supposed to be responding to infection," Mortimer says. "The venom essentially sucks the calcium out of the fly's blood cells."

    The experiments showed that the wasp venom is specifically targeted to the fly blood cells, and has no effect on other cells.

    An unresolved question is how a SERCA protein, which is hydrophobic and normally resides in an oily membrane, moves out of a wasp venom cell and makes its way into a fly blood cell.

    "We have no idea how it works," Schlenke says, "but somehow this calcium pump moves through all these environments and finds its way into its target cells."

    The researchers hypothesize that virus-like particles in the wasp's venom may be involved. "If they aren't really viruses, they seem to be some virus-like thing that the wasp has invented," Schlenke says. "It's pure speculation, but we think maybe the wasps use these particles as delivery vehicles for the calcium pumps."

    Previous research has established that fruit fly immune signaling pathways have homologues in humans, making fruit flies a valuable model for learning about human immunity. That work led to the award of the 2011 Nobel Prize in physiology or medicine to Jules Hoffmann, a fruit fly immunologist.

    Studying the wasp-fly battle for survival at the molecular level provides a powerful new tool for unlocking more secrets of immunity that could apply to human health, Mortimer says.

    "I'm also interested in using the flies to understand more about the immune systems of mosquitos and other insect vectors of human disease," he says. "If we could somehow boost vector insect immunity, it could decrease transmission of human disease like malaria."

    ###

    Emory Health Sciences: http://whsc.emory.edu/home/news/index.html

    Thanks to Emory Health Sciences for this article.

    This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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    Source: http://www.labspaces.net/128318/Parasitic_wasps_use_calcium_pump_to_block_fruit_fly_immunity

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